Mana-Zucca was born Gisella Zuckermann in New York City. She started studying the piano at the age of four on scholarship at the National Conservatory of Music in New York. At age seven, she began piano lessons at the New York College of Music. That same year she performed the Beethoven C major Piano Concerto in Carnegie Hall with the New York Symphony Orchestra. The ensuing years proved fruitful for Mana-Zucca as composer. Her Fugato and Novelette were performed by the Cincinnati Symphony Orchestra in 1917, followed by performances by the New York Philharmonic Orchestra under the baton of Josef Stransky, and by the Los Angeles Symphony Orchestra in Pasadena. She was soloist in her Piano Concerto with the Los Angeles Symphony in August 1919 under the baton of Arnold Volpe, and again at New York's Lewisohn Stadium with Henry Hadley on the podium. She wrote over 1,000 works by her own count, including numerous songs, chamber music, and many piano pieces. For further information, see "Women Composers: Music Through the Ages," volume VI and HPC 02043.